Functional connectivity of cortical motor areas in the resting state in Parkinson's disease
Identifieur interne : 000312 ( Main/Exploration ); précédent : 000311; suivant : 000313Functional connectivity of cortical motor areas in the resting state in Parkinson's disease
Auteurs : Tao Wu [République populaire de Chine] ; Xiangyu Long [République populaire de Chine] ; Liang Wang [République populaire de Chine] ; Mark Hallett [États-Unis] ; Yufeng Zang [République populaire de Chine] ; Kuncheng Li [République populaire de Chine] ; Piu Chan [République populaire de Chine]Source :
- Human Brain Mapping [ 1065-9471 ] ; 2011-09.
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Abstract
Parkinson's disease (PD) patients have difficulty in initiating movements. Previous studies have suggested that the abnormal brain activity may happen not only during performance of self‐initiated movements but also in the before movement (baseline or resting) state. In the current study, we investigated the functional connectivity of brain networks in the resting state in PD. We chose the rostral supplementary motor area (pre‐SMA) and bilateral primary motor cortex (M1) as “seed” regions, because the pre‐SMA is important in motor preparation, whereas the M1 is critical in motor execution. FMRIs were acquired in 18 patients and 18 matched controls. We found that in the resting state, the pattern of connectivity with both the pre‐SMA or the M1 was changed in PD. Connectivity with the pre‐SMA in patients with PD compared to normal subjects was increased connectivity to the right M1 and decreased to the left putamen, right insula, right premotor cortex, and left inferior parietal lobule. We only found stronger connectivity in the M1 with its own local region in patients with PD compared to controls. Our findings demonstrate that the interactions of brain networks are abnormal in PD in the resting state. There are more connectivity changes of networks related to motor preparation and initiation than to networks of motor execution in PD. We postulate that these disrupted connections indicate a lack of readiness for movement and may be partly responsible for difficulty in initiating movements in PD. Hum Brain Mapp, 2010. © 2010 Wiley‐Liss, Inc.
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DOI: 10.1002/hbm.21118
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Brain Mapp.</title><idno type="ISSN">1065-9471</idno><idno type="eISSN">1097-0193</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2011-09">2011-09</date><biblScope unit="volume">32</biblScope><biblScope unit="issue">9</biblScope><biblScope unit="page" from="1443">1443</biblScope><biblScope unit="page" to="1457">1457</biblScope></imprint><idno type="ISSN">1065-9471</idno></series><idno type="istex">FA9B85FC541373204B9B38C1AC4D7A17B749DCAE</idno><idno type="DOI">10.1002/hbm.21118</idno><idno type="ArticleID">HBM21118</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1065-9471</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Parkinson's disease</term><term>functional connectivity</term><term>primary motor cortex</term><term>resting state</term><term>rostral supplementary motor area</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Parkinson's disease (PD) patients have difficulty in initiating movements. Previous studies have suggested that the abnormal brain activity may happen not only during performance of self‐initiated movements but also in the before movement (baseline or resting) state. In the current study, we investigated the functional connectivity of brain networks in the resting state in PD. We chose the rostral supplementary motor area (pre‐SMA) and bilateral primary motor cortex (M1) as “seed” regions, because the pre‐SMA is important in motor preparation, whereas the M1 is critical in motor execution. FMRIs were acquired in 18 patients and 18 matched controls. We found that in the resting state, the pattern of connectivity with both the pre‐SMA or the M1 was changed in PD. Connectivity with the pre‐SMA in patients with PD compared to normal subjects was increased connectivity to the right M1 and decreased to the left putamen, right insula, right premotor cortex, and left inferior parietal lobule. We only found stronger connectivity in the M1 with its own local region in patients with PD compared to controls. Our findings demonstrate that the interactions of brain networks are abnormal in PD in the resting state. There are more connectivity changes of networks related to motor preparation and initiation than to networks of motor execution in PD. We postulate that these disrupted connections indicate a lack of readiness for movement and may be partly responsible for difficulty in initiating movements in PD. Hum Brain Mapp, 2010. © 2010 Wiley‐Liss, Inc.</div></front></TEI><affiliations><list><country><li>République populaire de Chine</li><li>États-Unis</li></country><region><li>Maryland</li></region><settlement><li>Pékin</li></settlement></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Wu, Tao" sort="Wu, Tao" uniqKey="Wu T" first="Tao" last="Wu">Tao Wu</name></noRegion><name sortKey="Chan, Piu" sort="Chan, Piu" uniqKey="Chan P" first="Piu" last="Chan">Piu Chan</name><name sortKey="Li, Kuncheng" sort="Li, Kuncheng" uniqKey="Li K" first="Kuncheng" last="Li">Kuncheng Li</name><name sortKey="Long, Xiangyu" sort="Long, Xiangyu" uniqKey="Long X" first="Xiangyu" last="Long">Xiangyu Long</name><name sortKey="Wang, Liang" sort="Wang, Liang" uniqKey="Wang L" first="Liang" last="Wang">Liang Wang</name><name sortKey="Zang, Yufeng" sort="Zang, Yufeng" uniqKey="Zang Y" first="Yufeng" last="Zang">Yufeng Zang</name></country><country name="États-Unis"><region name="Maryland"><name sortKey="Hallett, Mark" sort="Hallett, Mark" uniqKey="Hallett M" first="Mark" last="Hallett">Mark Hallett</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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